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Halozyme to Restructure After Pancreatic Cancer Drug Fails in Phase 3

Xconomy

An experimental Halozyme Therapeutics treatment for pancreatic cancer has failed a pivotal study, and the company is stopping further development of the drug and closing its oncology operations as part of a corporate restructuring.

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Bio Roundup: Theranos Cuts, Alnylam Stops, Nobel Eats Its Own & More

Xconomy

—Alnylam Pharmaceuticals (NASDAQ: ALNY ) of Cambridge, MA, said that it would shelve its drug revusiran after 18 patients died in a Phase 3 study to treat the rare disease transthyretin amyloidosis. —Merrimack Pharmaceuticals (NASDAQ: MACK ) announced layoffs of 22 percent of its staff and the resignation of CEO Robert Mulroy.

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Biotech Roundup: Hellos, Goodbyes, “Cures” Delays And Trial News

Xconomy

Our San Diego editor Bruce Bigelow penned a personal goodbye to entrepreneur Larry Bock, who died last week of pancreatic cancer at the age of 56. After last week’s revelation of three patient deaths in its leading cancer immunotherapy trial, the FDA suspended the study. The week started on a reflective note.

News 40
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Biotech Roundup: Kadmon Debt, Hemo Data, Loose Lips & More

Xconomy

. —All the while, Merck (NYSE: MRK ) disclosed pembrolizumab (Keytruda) bested chemotherapy in a Phase 3 trial of previously untreated patients with non-small cell lung cancer; the study was stopped early because of the positive results.

News 55
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Bio Roundup: Bosley’s Editas Exit, Bridge Bucks, CRISPR Crime & More

Xconomy

In a week of big personnel moves, none was more surprising than Editas Medicine CEO Katrine Bosley’s departure.

Guide 63
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Bio Roundup: Senate Drama, A.I. Stories, Data Dives, Shkreli & More

Xconomy

There is no Obamacare replacement, at least not as of this writing. The Senate Republicans are fractured, with a handful of conservatives and moderates each giving a cold shoulder to their chamber’s version of healthcare reform, the Better Care Reconciliation Act.

Writing 56
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Bio Roundup: Phase 3 Fails, Shkreli Jailed, Moderna Flip-Flops & More

Xconomy

It was a week of realignments. President Trump, who used to be known as “The Donald” but now goes by “ Amnesty Don ,” kept up the parlay-voo with his new friends Chuck and Nancy. Martin Shkreli, who was once known— and still is!